Votre navigateur est obsolète !

Pour une expériencenet et une sécurité optimale, mettez à jour votre navigateur. Mettre à jour maintenant

×

Benoît Serive

Contact

E-mail

Professional Status

Available soon
Available

About Me

Laureate of the vocation award 2006
(Bleustein Blanchet Fundation)


Laureate 2013 - Marie Curie Outgoing Fellowship
OCEANCHArCoT programm


Member of the French Speaking Network of Metabolomics and Fluxomics


Member of the French Speaking Society of Pharmacognosy


Member of the American Society of Pharmacognosy


Member of the Association for the Sciences of Limnology and Oceanography


Reviewer for scientific peer-reviewed journals :
Marine Drugs, Algal Research


Invited Speaker at the 5th World Congress on Biotechnology (Valencia, Spain, June 2014)



In brief :

Voluntary, passionate and sensitive to human values​​, I want to use my skills to the search for molecules with high added value from marine biodiversity.



Last supervisors :


Dr. Stéphane BACH
(CNRS, Roscoff, France)

Prof. Ronald J. QUINN
(Eskitis Institute for Drug Discovery, Brisbane, Australia)



Mentor :

Emeritus Prof. Jean-Michel KORNPROBST
(University of Nantes, France)

Experience

Project holder in marine biotechnology

Company under development
Since June 2018
Company Description

Further information​ soon

Post-doctoral researcher position (Marie Skłodowska-Curie program)

Station biologique de Roscoff - CNRS
June 2014 to June 2017
Responsibilities completed
  • OCEANCHArCoT program: OCEAN CHemodiversity Against Cell cycle Targets
  • Development of a microalgae dereplication strategy assisted with metabolomics tools
  • Exploration of signaling pathways hit by marine metabolites of interest
  • Mode of action of marine metabolites using bioassays, flow cytometry, epifluorescence microscopy
  • Marine bioresources valorization (cosmetoceuticals, nutraceutics, feed/aquaculture)
  • Involvement in OCEANOMICs Axis 7: Innovation platform for plankton screening for bioactive compounds and metabolites

Postdoctoral research position (Marie Skłodowska-Curie program)

Griffith Institute for Drug Discovery - Griffith University
July 2014 to August 2016
Responsibilities completed
  • OCEANCHArCoT program: OCEAN CHemodiversity Against Cell cycle Targets
  • Lead-Like Enhanced Fractions production and screening (HTS)
  • Evaluation of marine fractions from Great Barrier Reef organisms against biological model
  • NMR fingerprint dereplication
Detailed Description
  • Aim: Research of new marine inhibitors targeted against desease-relevant proteins kinases

    These latter are involved in various human pathologies such as cancer, neurodegenerative diseases or can be targeted to alter the life cycle of various parasites such as those responsible neglected parasitic diseases such as leishmaniasis and malaria. There are no physiological events not involving significant changes in protein phosphorylation. Therefore, PKs constitute currently the first class of targets used by pharmaceutical companies for the characterization of novel bioactive compounds. In a project intended to exploit the ocean biodiversity, Jean-Baptiste Charcot (1867-1936), a pioneer in oceanography established large collections of marine organisms. Taking this one step further, my project aims to source marine crude extracts from the Nature Bank collection (QLD, Australia), and from the unique Roscoff Culture Collection of microalgae (France) to identify new PK inhibitors. We will focus our analysis on PKs involved in the control of the cell division cycle (CDKs, TLKs and mitotic kinases such as Haspin and Auroras). The cellular effect of the selected inhibitors will be analysed on various cancer cell lines. This project will benefit from a new cutting edge technology will be used for the early screening of marine chemodiversity: bioaffinity (focused on PKs) mass spectrometry with a Bruker SolariX 12 Tesla FTMS. The lead-like enhanced fractions will be tested against various disease models and dereplicated in order to quickly identify bioactive molecules. Hit fractions will be produced in larger quantity before purification, characterization and pharmacological evaluation. In conclusion, OCEANCHArCoT will contribute, from Australia to France, to the research of marine bioactives to discover new therapeutic avenues to fight growing medical and social burdens such as cancer and Alzheimer’s disease.

PhD student

IFREMER-Laboratory of Physiology and Biotechnology of Algae
March 2009 to December 2012
Responsibilities completed
  • Research and production of metabolites of interest in photodynamic therapy from photosynthetic micro-organisms
    (Work under confidentiality clauses)
  • Microalgae and cyanobacteria cultures
  • Development of a biotest to assess a specific activity potentially interesting for high throughput screening
  • Comparison of cell grinding methods by design of experiments methodology
  • Optimization of the extraction of specific molecules of interest
  • Development of a dereplication method for target molecules using hyphenated HPLC-UV DAD
  • Purification by high performance liquid chromatography
  • Image analysis
  • Flow cytometry
Detailed Description
  • Valorization of molecules by patent pending
  • Valorization in Bioresource Technology 124 : 311-320 (Serive et al, 2012)
  • Pigment analysis of Isochrysis afinis galbana strains for the team Algae & Genome from Laboratory PBA (IFREMER)
  • Pigment comparisons of dinoflagellate strains for the phycotoxins laboratory (IFREMER)
  • Glaucophyta strain pigment study
  • Pigment composition of 45 strains of photosynthetic micro-organisms
Company Description

Laboratory devoted mainly to biotechnological applications of microalgae and the study of their metabolism

Company website

http://wwz.ifremer.fr/pba/layout/set/print/Presentation

Postgraduate student (EPHE)

Research group Sea Molecules Health - University of Nantes
September 2007 to July 2008
Responsibilities completed
  • Extraction, purification, characterization of marine phospholipids and sterols
  • Scuba-diving expedition for collection of sponges, cnidarians, echinoderms
  • Analysis and purification by analytical and preparative thin layer chromatography
  • Purification by high performance liquid chromatography
  • Analysis by hyphenated gas chromatography/mass spectrometry
Company Description

Laboratory dedicated to studying marine chemical molecules of interest

Company website

http://www.mms.univ-nantes.fr

Postgraduate student (EPHE)

Laboratory of Marine Biotechnology and Chemistry - University of South britany
January 2006 to August 2007
Responsibilities completed
  • Development of screening bioassays
  • Cell culture (human cell lines, bacteria, virus)
  • Anti-viral bioassays
  • Anti-bacteria bioassays
  • Anti-fouling bioassays
  • Tests in cosmetology (anti-free radicals, anti-elastase, anti-oxidant, anti-inflammatory, cytotoxicity)
Company Description

Laboratory dedicated to research of biological activities from marine extracts

Company website

http://www-lbcm.univ-ubs.fr/

Undergraduate student (Intechmer)

IFREMER - Laboratory of Invertebrates Physiology
April 2004 to August 2004
Responsibilities completed
  • Search for alternatives to the use of chloramphenicol in scallop larvae breeding (Pecten maximus)
  • Larval breeding
  • Microalgae culture (batch and continuous mode)
  • Microbiology techniques
  • Bioassays (cytotoxicity and growth inhibition)
  • Image analysis
Company Description

Laboratory dedicated to the study of invertebrates for aquaculture

Company website

http://wwz.ifremer.fr/pfompi

Undergraduate student (Halieutic)

IFREMER - Port en Bessin
January 2003
Responsibilities completed
  • Boarding for assess mussel stocks for the opening of the commercial fishermen fishing in the North Cotentin
Detailed Description
  • Biometrics
Responsibilities completed
  • Sample collection on the foreshore
  • Taxonomic determination
  • Immunological analyzes of filter-feeding bivalves
  • Transect
Company Description

Teaching and research in ecology of marine ecosystems, animal and plant ecology, biological, ecological monitoring

Undergraduate student (Shellfish farming)

Oyster company Billon J-Y
September 1999 to May 2001
Responsibilities completed
  • Techno-economic study: controlled fattening of the oyster Crassostrea gigas by the diatom Skeletonema costatum
Detailed Description
  • Long training period (15 months full-time equivalent)
  • Detrockage, tides, packaging, technical and economic study of the project (including feasibility, accounting estimates)
Company Description

Farming of Pacific oysters, sales on markets

Undergraduate student (Marine biology)

IFREMER - Coastal station Bouin
September 2001
Responsibilities completed
  • Collection of field samples
  • Sample sorting
  • Counting and biometrics
Detailed Description
  • Participation in the evaluation study of biomass and density of the cockle Cerastoderma edule cultured in the Traict Croisic
Company website

http://www.ifremer.fr/lcpl/

Undergraduate student (Algoculture)

Innovalg
June 2000 to July 2000
Responsibilities completed
  • Microalgae counting
  • Harvesting and sorting of biomass
  • Packaging of microalgae paste
  • Review : The French industry of macroalgae
Company Description

Co-culture of microalgae and macroalgae in raceway (mainly Chondrus crispus and Odontella aurita)

Undergraduate student (Shellfish farming)

Mussel company Lamarche Y.
September 1999 to December 1999
Responsibilities completed
  • Mussel sorting
  • "Boudinage"
  • "Catinage"
  • Packaging
Company Description

Mussel farming

Undergraduate student (Marine biology)

Marine aquarium
April 1999 to May 1999
Responsibilities completed
  • Feeding
  • Cleaning the aquarium
  • Guided tours to school groups
Company Description

Public marine aquarium

Undergraduate student (Fishfarming)

France Turbot 2
February 1999 to March 1999
Responsibilities completed
  • Manual sorting of turbot (depending on size and malformations)
  • Tanks parameter control
  • Preparation of granules diets
  • Feeding
  • Fishing of turbots
Company Description

Larval rearing of turbot (nursery unit)

Company website

http://www.adrien.fr/web/p184_france-turbot.html

Undergraduate student (Shellfish farming)

Vendée Naissaim
September 1998
Responsibilities completed
  • Spat oyster sorting
  • Feeding in micronursery
  • Washing sieves
  • Spat counting
  • Packaging of spat
Company Description

Spat farming of oysters and clams

Company website

http://www.francenaissain.com/

Undergraduate student (Fishfarming)

Marine farm des Etiers
July 1998
Responsibilities completed
  • Fishing with a seine
  • Feeding
  • Sorting
  • Direct selling
  • Defouling of tanks
Company Description

Breeding seabass, gilt-head, turbot, prawns

Undergraduate student (Shellfish farming)

Various oyster companies
April 1998 to June 1999
Responsibilities completed
  • Company Sachot G.
  • Company Robin J-C.
  • Company Lamarche S.
  • Company Robard J-P.

Undergraduate student (Fishfarming)

France Turbot 1
March 1998
Responsibilities completed
  • Manual sorting of turbot (depending on size and malformations)
  • Mechanical sorting of turbot (depending on size)
  • Vaccination of turbot by bathing
  • Preparation of granules diets
  • Feeding
  • Fishing of turbots
Company Description

Larval rearing of turbot (weaning, nursery and pre-fattening)

Company website

http://www.adrien.fr/web/p184_france-turbot.html