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Benoît Serive

Contact

E-mail

Professional Status

Available soon
Available

About Me

Laureate of the vocation award 2006
(Bleustein Blanchet Fundation)


Laureate 2013 - Marie Curie Outgoing Fellowship
OCEANCHArCoT programm


Member of the French Speaking Network of Metabolomics and Fluxomics


Member of the French Speaking Society of Pharmacognosy


Member of the American Society of Pharmacognosy


Member of the Association for the Sciences of Limnology and Oceanography


Reviewer for scientific peer-reviewed journals :
Marine Drugs, Algal Research


Invited Speaker at the 5th World Congress on Biotechnology (Valencia, Spain, June 2014)



In brief :

Voluntary, passionate and sensitive to human values​​, I want to use my skills to the search for molecules with high added value from marine biodiversity.



Last supervisors :


Dr. Stéphane BACH
(CNRS, Roscoff, France)

Prof. Ronald J. QUINN
(Eskitis Institute for Drug Discovery, Brisbane, Australia)



Mentor :

Emeritus Prof. Jean-Michel KORNPROBST
(University of Nantes, France)

Experience

Project holder in marine biotechnology

Company under development
Since June 2018

Post-doctoral researcher position (Marie Skłodowska-Curie program)

Station biologique de Roscoff - CNRS
June 2014 to June 2017
  • OCEANCHArCoT program: OCEAN CHemodiversity Against Cell cycle Targets
  • Development of a microalgae dereplication strategy assisted with metabolomics tools
  • Exploration of signaling pathways hit by marine metabolites of interest
  • Mode of action of marine metabolites using bioassays, flow cytometry, epifluorescence microscopy
  • Marine bioresources valorization (cosmetoceuticals, nutraceutics, feed/aquaculture)
  • Involvement in OCEANOMICs Axis 7: Innovation platform for plankton screening for bioactive compounds and metabolites

Postdoctoral research position (Marie Skłodowska-Curie program)

Griffith Institute for Drug Discovery - Griffith University
July 2014 to August 2016
  • OCEANCHArCoT program: OCEAN CHemodiversity Against Cell cycle Targets
  • Lead-Like Enhanced Fractions production and screening (HTS)
  • Evaluation of marine fractions from Great Barrier Reef organisms against biological model
  • NMR fingerprint dereplication

PhD student

IFREMER-Laboratory of Physiology and Biotechnology of Algae
March 2009 to December 2012
  • Research and production of metabolites of interest in photodynamic therapy from photosynthetic micro-organisms
    (Work under confidentiality clauses)
  • Microalgae and cyanobacteria cultures
  • Development of a biotest to assess a specific activity potentially interesting for high throughput screening
  • Comparison of cell grinding methods by design of experiments methodology
  • Optimization of the extraction of specific molecules of interest
  • Development of a dereplication method for target molecules using hyphenated HPLC-UV DAD
  • Purification by high performance liquid chromatography
  • Image analysis
  • Flow cytometry

Postgraduate student (EPHE)

Research group Sea Molecules Health - University of Nantes
September 2007 to July 2008
  • Extraction, purification, characterization of marine phospholipids and sterols
  • Scuba-diving expedition for collection of sponges, cnidarians, echinoderms
  • Analysis and purification by analytical and preparative thin layer chromatography
  • Purification by high performance liquid chromatography
  • Analysis by hyphenated gas chromatography/mass spectrometry

Postgraduate student (EPHE)

Laboratory of Marine Biotechnology and Chemistry - University of South britany
January 2006 to August 2007
  • Development of screening bioassays
  • Cell culture (human cell lines, bacteria, virus)
  • Anti-viral bioassays
  • Anti-bacteria bioassays
  • Anti-fouling bioassays
  • Tests in cosmetology (anti-free radicals, anti-elastase, anti-oxidant, anti-inflammatory, cytotoxicity)

Undergraduate student (Intechmer)

IFREMER - Laboratory of Invertebrates Physiology
April 2004 to August 2004
  • Search for alternatives to the use of chloramphenicol in scallop larvae breeding (Pecten maximus)
  • Larval breeding
  • Microalgae culture (batch and continuous mode)
  • Microbiology techniques
  • Bioassays (cytotoxicity and growth inhibition)
  • Image analysis

Education

PhD of Science speciality in biomolecules, pharmacology and therapy

PhD school VENAM - University of Nantes
March 2009 to December 2012

MSc in medical and biological science research specialising in Mechanisms and optimisation of marine bioproduction

University of Nantes - Faculty of Sciences and Techniques
September 2007 to June 2008

Marine pharmacognosy, aquaculture, maritime Law, marine biology

MSc in Cell signalling and integrated systems in biology

Practical School of High Studies (EPHE)
September 2006 to July 2008

Cellular and molecular biology, cancerology, flow cytometry, virology

BSc in Biochemistry-Molecular biology

University of Nantes - Faculty of Sciences and Techniques
September 2004 to March 2006

Enzymology, biochemistry, molecular biology, bio-organic chemistry, integration of metabolic pathways

Physical and biological oceanography, marine zoology, algology, aquariology, marine geology, fisheries, aquaculture

Intensive course in science subjects

UCO - Institute of applied mathematics
September 2001 to June 2002

National diploma in aquaculture

MFR Les Plantes
September 1999 to July 2001

Aquaculture technologies, economy, accounting

First diploma in marine cultures

MFR Les Plantes
September 1997 to July 1999

Study of breeding and culture techniques of marine species, marine biology

Skills

  • Pigment analysis by means of HPLC-UV DAD
  • Optimized extraction of photosynthetic microorganisms
  • Purification and culture of microalgae strains
  • Purification of marine natural products
  • Development testing of biological activities (anti-fouling, cosmetology, pharmacology)
  • Development of a screening strategy for pharmacological activity
  • Collection of marine organisms for studies in scuba-diving
  • Light microscopy
    (cell counting and image analysis)
  • Cell culture (human cell lines and animal cell lines, viruses)
  • Basics of flow cytometry on Accuri C6
  • Basic microbiology techniques (isolation, culture, bioassay)
  • Scientific and technological reporting
    (patent database)
  • Studies in experimental designs (factors screening and optimization)
  • Statistical analysis of data (Statgraphics, Xlstat, Matlab)
  • Development and project management
    (Gantt, Mind Mapping on Mindmanager, quotations, inventory management)
  • Drafting of specifications
  • Results reporting
  • Collaborations with external laboratories (LEMAR Brest, Nantes University Hospital, platform BIODIMAR Brest, Nantes Phycotoxins Laboratory, Veolia Environment)
  • Publication in refereed journals
  • Scientific networking
  • Popular science (World Oceans Day, Square of Science, Science Fair, foreshore visit)

Interests

  • Study on the microalgal pigments extraction process: performance of microwave-assisted extraction (2011) Process Biochemistry 46: 59-67
  • Antiproliferative activity of violaxanthin isolated from bioguided fractionation of Dunaliella tertiolecta extracts (2011) Marine Drugs 9: 819-831
  • Selection and optimisation of a method for efficient metabolites extraction from microalgae (2012) Bioresource Technology 124: 311-320
  • Screening marine resources to find novel chemical inhibitors of disease-relevant protein kinases (2015) Medecine/Sciences 31(5): 538-545
  • Community analysis of pigment patterns from 37 microalgae strains reveals new carotenoids and porphyrins characteristic of distinct strains and taxonomic groups (2017) PLoS One 12(2): 1-35
  • Constituents of Acacia nilotica (L.) Delile with novel kinase inhibitory activity (2017) Planta Medica International Open 4:108-113
  • Marine pigment diversity: applications and potential (2018, in process) In: Blue Biotechnology: production and use of marine molecules
  • Microalgal biomass of industrial interest: methods of characterization (2018, in process) In: Biomass, waste and related by-products characterization
  • Scuba-diving
  • Surfing
  • Swimming
  • Kayaking
  • Tai-chi-chuan
  • Apnea
  • Senegal
  • Germany
  • Scotland
  • USA
  • Australia
  • Portugal
  • Fiji
  • Norway
  • Aquariophilly
  • Oenology